Gut microbiome heritability is nearly universal but environmentally contingent - ID 12949

Alias: ABRP Microbiome
Abstract: Relatives have more similar gut microbiomes than nonrelatives, but the degree to which this similarity results from shared genotypes versus shared environments has been controversial. Here, we leveraged 16,234 gut microbiome profiles, collected over 14 years from 585 wild baboons, to reveal that host genetic effects on the gut microbiome are nearly universal. Controlling for diet, age, and socioecological variation, 97% of microbiome phenotypes were significantly heritable, including several reported as heritable in humans. Heritability was typically low (mean = 0.068) but was systematically greater in the dry season, with low diet diversity, and in older hosts. We show that longitudinal profiles and large sample sizes are crucial to quantifying microbiome heritability, and indicate scope for selection on microbiome characteristics as a host phenotype.
Description: For more information regarding the Amboseli Baboon Research Project, see link: https://amboselibaboons.nd.edu/about-the-project/
Owner: bjork.johannes@gmail.com
Publications: 10.1126/science.aba5483
PI: Elizabeth A Archie (University of Notre Dame)
EBI: ERP119849 (submitted)
Artifacts
ID Data Type Platform Target Gene Target Subfragment Algorithm
85890     16S Illumina 16S rRNA V4 Trimming (length: 150)
86076     16S Illumina 16S rRNA V4 Trimming (length: 150)
86078     16S Illumina 16S rRNA V4 Trimming (length: 150)
86081     16S Illumina 16S rRNA V4 Trimming (length: 150)
86082     16S Illumina 16S rRNA V4 Trimming (length: 150)
86089     16S Illumina 16S rRNA V4 Trimming (length: 150)
86092     16S Illumina 16S rRNA V4 Trimming (length: 150)
86093     16S Illumina 16S rRNA V4 Trimming (length: 150)
86094     16S Illumina 16S rRNA V4 Trimming (length: 150)
86099     16S Illumina 16S rRNA V4 Trimming (length: 150)
86100     16S Illumina 16S rRNA V4 Trimming (length: 150)
86107     16S Illumina 16S rRNA V4 Trimming (length: 150)
86125     16S Illumina 16S rRNA V4 Trimming (length: 150)
94183     16S Illumina 16S rRNA V4 Trimming (length: 90)
94185     16S Illumina 16S rRNA V4 Trimming (length: 90)
94186     16S Illumina 16S rRNA V4 Trimming (length: 90)
94189     16S Illumina 16S rRNA V4 Trimming (length: 90)
94190     16S Illumina 16S rRNA V4 Trimming (length: 90)
94192     16S Illumina 16S rRNA V4 Trimming (length: 90)
94195     16S Illumina 16S rRNA V4 Trimming (length: 90)
94206     16S Illumina 16S rRNA V4 Trimming (length: 90)
94215     16S Illumina 16S rRNA V4 Trimming (length: 90)
94216     16S Illumina 16S rRNA V4 Trimming (length: 90)
94217     16S Illumina 16S rRNA V4 Trimming (length: 90)
94326     16S Illumina 16S rRNA V4 Trimming (length: 90)
94327     16S Illumina 16S rRNA V4 Trimming (length: 90)
85897     16S Illumina 16S rRNA V4 Pick closed-reference OTUs (reference-seq: /databases/gg/13_8/rep_set/97_otus.fasta) | Trimming (length: 150)
85863     16S Illumina 16S rRNA V4 Split libraries FASTQ
86022     16S Illumina 16S rRNA V4 Split libraries FASTQ
86023     16S Illumina 16S rRNA V4 Split libraries FASTQ
86024     16S Illumina 16S rRNA V4 Split libraries FASTQ
86027     16S Illumina 16S rRNA V4 Split libraries FASTQ
86074     16S Illumina 16S rRNA V4 Split libraries FASTQ
86077     16S Illumina 16S rRNA V4 Split libraries FASTQ
86079     16S Illumina 16S rRNA V4 Split libraries FASTQ
86080     16S Illumina 16S rRNA V4 Split libraries FASTQ
86083     16S Illumina 16S rRNA V4 Split libraries FASTQ
86084     16S Illumina 16S rRNA V4 Split libraries FASTQ
86087     16S Illumina 16S rRNA V4 Split libraries FASTQ
86088     16S Illumina 16S rRNA V4 Split libraries FASTQ
133036     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133037     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133113     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133114     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133592     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133593     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133596     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133597     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133600     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133602     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133624     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133625     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133657     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133658     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133699     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133700     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133701     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133702     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133743     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133744     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133757     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133758     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133764     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133765     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
133766     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 90)
133767     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 90)
134388     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134389     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134839     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134840     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134859     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134860     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134897     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134898     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134904     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134905     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134907     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134908     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134930     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134931     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
134969     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
134970     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135000     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135001     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
135002     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135003     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
135008     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135009     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
135012     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
135013     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135100     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: all.biom) | Trimming (length: 150)
135101     16S Illumina 16S rRNA V4 Deblur 2021.09 (Reference phylogeny for SEPP: Greengenes_13.8, BIOM: reference-hit.biom) | Trimming (length: 150)
85784     16S Illumina 16S rRNA V4
85923     16S Illumina 16S rRNA V4
85933     16S Illumina 16S rRNA V4
85938     16S Illumina 16S rRNA V4
85960     16S Illumina 16S rRNA V4
85966     16S Illumina 16S rRNA V4
85976     16S Illumina 16S rRNA V4
86006     16S Illumina 16S rRNA V4
86007     16S Illumina 16S rRNA V4
86008     16S Illumina 16S rRNA V4
86010     16S Illumina 16S rRNA V4
86011     16S Illumina 16S rRNA V4
86014     16S Illumina 16S rRNA V4