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Impact of Pathogen Colonization on Mouse Vaginal Microbiota

This project seeks to define the impact of three reproductive tract pathogens, Trichomonas vaginalis, Candida albicans, and Group B Streptococcus, on mucosal host immune responses and perturbations in vaginal native flora using mouse models of vaginal infection. T. vaginalis is the most common non-viral sexually transmitted pathogen and is associated with preterm birth, infertility and bacterial vaginosis. C. albicans is the primary pathogen in vulvovaginal candidiasis, a condition affecting up to 75% of women of child-bearing age, and is also linked to preterm birth and low birth weight. Group B Streptococcus (GBS), a frequent cause of neonatal sepsis and morbidity, is a commensal vaginal microbe which can also cause preterm birth and urinary tract infections. Together, these pathogens represent a collection of leading etiologic agents of infectious disease in the field of women’s reproductive health.

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