Generated on: 01-19-22 01:22:30

Studies Unique Samples per Visibility Status Public Samples per Data Type Users Jobs
public: 625
private: 170
sandbox: 2,005
submitted to EBI: 685
public: 304,576
private: 112,247
sandbox: 444,744
submitted to EBI: 247,675
submitted to EBI (prep): 283,934
16S: 302,133
18S: 8,769
ITS: 11,809
Metagenomic: 27,962
Full Length Operon: 803
Metatranscriptomic: 988
Metabolomic: 407
10,200 510,703

Check out this random public study from the database!

Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice

The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated immunization with a heat-killed preparation of Mycobacterium vaccae, an immu- noregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor in a murine model of chronic psychosocial stress when tested 1–2 wk following the final immunization. Furthermore, immunization with M. vaccae prevented stress-induced spontaneous colitis and, in stressed mice, induced anxiolytic or fear-reducing effects as mea- sured on the elevated plus-maze, despite stress-induced gut micro- biota changes characteristic of gut infection and colitis. Immunization with M. vaccae also prevented stress-induced aggravation of colitis in a model of inflammatory bowel disease. Depletion of regulatory T cells negated protective effects of immunization with M. vaccae on stress-induced colitis and anxiety-like or fear behaviors. These data provide a framework for developing microbiome- and immunoregu- lation-based strategies for prevention of stress-related pathologies.

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