Studies | Unique Samples per Visibility Status | Public Samples per Data Type | Users | Jobs |
---|---|---|---|---|
public: 831 private: 177 sandbox: 2,768 submitted to EBI: 914 |
public: 411,466 private: 121,006 sandbox: 606,529 submitted to EBI: 343,131 submitted to EBI (prep): 397,952 |
16S: 374,261 18S: 12,149 ITS: 14,649 Metagenomic: 68,280 Full Length Operon: 803 Metatranscriptomic: 26,395 Metabolomic: 1,545 Genome Isolate: 1,131 |
14,394 | 844,335 |
The relationship between gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity is still not well understood. Here we investigate these associations in a large African origin cohort from Ghana, South Africa, Jamaica, Seychelles, and the US. Fecal microbiota diversity and SCFA concentration are greatest in Ghanaians, and lowest in the US population, representing the lowest and highest end of the epidemiologic transition spectrum, respectively. Obesity is significantly associated with a reduction in SCFA concentration, microbial diversity and SCFA synthesizing bacteria. Country of origin can be accurately predicted from the fecal microbiota while the predictive accuracy for obesity is inversely correlated to the epidemiological transition, being greatest in Ghana. The findings suggest that the microbiota differences between obesity and non-obesity may be larger in low-to-middle-income countries compared to high-income countries. Further investigation is needed to determine the factors driving this association.