Studies | Unique Samples per Visibility Status | Public Samples per Data Type | Users | Jobs |
---|---|---|---|---|
public: 698 private: 155 sandbox: 2,330 submitted to EBI: 736 |
public: 373,866 private: 111,214 sandbox: 473,484 submitted to EBI: 274,745 submitted to EBI (prep): 324,537 |
16S: 342,835 18S: 8,896 ITS: 14,156 Metagenomic: 60,670 Full Length Operon: 803 Metatranscriptomic: 11,764 Metabolomic: 407 Genome Isolate: 1,131 |
11,822 | 666,147 |
Our project focuses on apurinic/apyrimidinic endonuclease (APE1), a multifunctional protein that regulates stress induced by carcinogenic infections. We developed a hypomorphic (HM) mouse that has facilitated studies of APE1 function throughout the body. The major finding is that the digestive tract is particularly susceptible to DNA damage when APE1 is compromised. The broad objective of this grant is to define how APE1 protects the digestive tract from DNA damage initiated by comensal bacteria