Generated on: 07-25-24 01:30:47

Studies Unique Samples per Visibility Status Public Samples per Data Type Users Jobs
public: 795
private: 171
sandbox: 2,587
submitted to EBI: 854
public: 395,778
private: 115,937
sandbox: 548,727
submitted to EBI: 317,044
submitted to EBI (prep): 370,718
16S: 364,651
18S: 12,052
ITS: 14,649
Metagenomic: 65,309
Full Length Operon: 803
Metatranscriptomic: 11,797
Metabolomic: 407
Genome Isolate: 1,131
13,288 785,683

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Bloodstream infections in patients with acute graft-versus-host disease treated with fecal microbiota transplantation a strain level source analysis

High rates of bloodstream infections were observed post-fecal microbiota transplantation (FMT) for graft-versus-host-disease. Using a metagenomic bioinformatic pipeline, we identified bacterial strains in patients' stool samples before emerging in the blood. Offending strains were absent from FMT donations. We present an approach for evaluating BSI origin following microbiota-based interventions. Our results support FMT safety in immunocompromised patients but do not rule out FMT as an inducer of bacterial translocation.

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