Generated on: 08-15-22 01:12:39

Studies Unique Samples per Visibility Status Public Samples per Data Type Users Jobs
public: 660
private: 167
sandbox: 2,145
submitted to EBI: 711
public: 348,213
private: 107,807
sandbox: 438,043
submitted to EBI: 262,725
submitted to EBI (prep): 306,659
16S: 321,713
18S: 8,896
ITS: 14,127
Metagenomic: 50,578
Full Length Operon: 803
Metatranscriptomic: 11,764
Metabolomic: 407
Genome Isolate: 1,131
10,775 576,634

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Meta-omics analysis of periodontal pocket microbial communities pre- and post-treatment

Periodontal disease affects the majority of adults worldwide and has been linked to numerous systemic diseases. Despite decades of research, the reasons for the substantial differences among periodontitis patients in disease incidence, progressivity and response to treatment remain poorly understood. While deep sequencing oral bacterial communities has greatly expanded our comprehension of the microbial diversity of periodontal disease and identified associations with healthy and disease states, predicting treatment outcomes remains elusive. Our results suggest that combining multiple ‘omics approaches enhances the ability to differentiate among disease states and determine differential effects of treatment, particularly with the addition of metabolomic information. Furthermore, multi-omics analysis of biofilm community instability indicated these approaches provide new tools for investigating the ecological dynamics underlying the progressive periodontal disease process.

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