Generated on: 04-20-24 01:40:55

Studies Unique Samples per Visibility Status Public Samples per Data Type Users Jobs
public: 737
private: 171
sandbox: 2,594
submitted to EBI: 838
public: 390,559
private: 115,579
sandbox: 539,152
submitted to EBI: 307,807
submitted to EBI (prep): 364,171
16S: 359,907
18S: 11,982
ITS: 14,640
Metagenomic: 64,696
Full Length Operon: 803
Metatranscriptomic: 11,764
Metabolomic: 407
Genome Isolate: 1,131
12,985 754,586

Check out this random public study from the database!

Staphylococcus Seed Grant Project

Staphylococcus aureus is gram-positive bacterial pathogen capable of asymptomatically colonizing about a third of the world population. This pathogen is the most common cause of nosocomial infections and a leading cause of death in hospitalized patients. The ability of S. aureus to colonize several environments is due to the presence of a variety of virulence factors that facilitate attachment, colonization, cell-cell interactions, tissue damage, dissemination through the body, and immune evasion. S. aureus infection is a frequent problem encountered by patients with Atopic Dermatitis (AD), with bacterial colonization observed on both lesional and nonlesional skin. AD, commonly known as eczema, is a complex disease. Its progression and severity depend on genetic risk factors (e.g. loss-of-function mutations in the gene encoding filaggrin), altered microbiota, and exposure to allergens. Another important factor, often neglected, is the effect of skin colonization by different strains of S. aureus, with distinct metabolic capability and pathogenicity. Although various S. aureus genomes are currently available in public repositories, the lack of information about the original source of isolation (AD skin, respiratory tract), patient clinical data, and the difficulty into obtaining available bacterial isolates, complicates strain characterization and AD contextualization. However, to accurately understand how interactions are established with the host and other bacteria and to develop targeted interventions, it is crucial to discriminate between different strains. We propose a comprehensive study to better characterize S. aureus strains from healthy people and patients with atopic dermatitis.

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