Generated on: 07-25-26 02:04:49

Studies Unique Samples per Visibility Status Public Samples per Data Type Users Jobs
public: 883
private: 176
sandbox: 2,967
submitted to EBI: 1,145
public: 437,509
private: 118,594
sandbox: 657,581
submitted to EBI: 388,873
submitted to EBI (prep): 450,795
16S: 388,713
18S: 12,149
ITS: 15,550
Metagenomic: 106,100
Full Length Operon: 803
Metatranscriptomic: 27,161
Metabolomic: 1,545
Genome Isolate: 1,505
17,056 933,894

Check out this random public study from the database!

Diet rapidly and reproducibly alters the human gut microbiome

Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut1 but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Here we show that the short-term consumption of diets composed entirely of animal or plant products alters microbial community structure and overwhelms inter-individual differences in microbial gene expression. The animal-based diet increased the abundance of bile-tolerant microorganisms (Alistipes, Bilophila and Bacteroides) and decreased the levels of Firmicutes that metabolize dietary plant polysaccharides (Roseburia, Eubacterium rectale and Ruminococcus bromii). Microbial activity mirrored differences between herbivorous and carnivorous mammals, reflecting trade-offs between carbohydrate and protein fermentation. Foodborne microbes from both diets transiently colonized the gut, including bacteria, fungi and even viruses. Finally, increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorganisms capable of triggering inflammatory bowel disease. In concert, these results demonstrate that the gut microbiome can rapidly respond to altered diet, potentially facilitating the diversity of human dietary lifestyles.

Log in above to see this and other public studies

Data usage